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NSC 745887
CAS No. 54490-26-5
NSC 745887 ( NSC745887 )
Catalog No. M14957 CAS No. 54490-26-5
NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNSC 745887
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
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DescriptionNSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways; increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage; suppresses the [18F]-FDG-specific uptake value in brain tumors.
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SynonymsNSC745887
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number54490-26-5
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Formula Weight260.25
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Molecular FormulaC16H8N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
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Chemical NameNaphtho[2,3-f]quinoxaline-7,12-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.
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