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NSC 745887

CAS No. 54490-26-5

NSC 745887( NSC745887 )

Catalog No. M14957 CAS No. 54490-26-5

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 745887
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
  • Description
    NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways; increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage; suppresses the [18F]-FDG-specific uptake value in brain tumors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC745887
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    54490-26-5
  • Formula Weight
    260.252
  • Molecular Formula
    C16H8N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
  • Chemical Name
    Naphtho[2,3-f]quinoxaline-7,12-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.
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