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NSC 745887

CAS No. 54490-26-5

NSC 745887 ( NSC745887 )

Catalog No. M14957 CAS No. 54490-26-5

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NSC 745887
Note

Research use only, not for human use.
Brief Description

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
Description

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways; increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage; suppresses the [18F]-FDG-specific uptake value in brain tumors.
Synonyms

NSC745887
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

54490-26-5
Formula Weight

260.25
Molecular Formula

C16H8N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Chemical Name

Naphtho[2,3-f]quinoxaline-7,12-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.

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